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KMID : 1134820090380121685
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Journal of the Korean Society of Food Science and Nutrition
2009 Volume.38 No. 12 p.1685 ~ p.1690
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Suppressive Effects of Chrysanthemum zawadskii var. latilobum Flower Extracts on Nitric Oxide Production and Inducible Nitric Oxide Synthase Expression
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Han Ji-Young
Kim Young-Wha
Seong Ji-Hae
Um Yu-Rry
Lee Yi
Lee Jun-Soo
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Abstract
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In this study, we investigated the effect of C. zawadskii extract on nitric oxide (NO) production, prostaglandin E2 (PGE2) production, protein and mRNA expression of inducible nitric oxide synthase (iNOS) in LPS-induced RAW 264.7 macrophage cells. C. zawadskii extract (5~50 ㎍/mL) significantly inhibited LPS-induced NO production in a concentration-dependent manner ranging from 23.3% to 100%. Consistent with the inhibitory effect on NO production, C. zawadskii extract inhibited the protein expression and mRNA expression of iNOS. Although flower extracts of C. zawadskii was not effective on the expression of PGE2 and COX-2, flower extracts of C. zawadskii, however, showed a strong anti-inflammatory activity through inhibition of NO production and iNOS expression. The present results suggest that C. zawadskii extract has an inhibitory effect on NO production, and thus can be used as an anti-inflammatory agent.
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KEYWORD
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Chrysanthemum zawadskii, anti-inflammation, nitric oxide, inducible nitric oxide synthase
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